Jason Unrine

Jason Unrine
Professor

Professional Profile

RESEARCH

  

I’m an environmental toxicologist and chemist.  My research activity falls into four major interdisciplinary areas focused on distinct societal challenges.  My research group works to help solve these challenges by working collaboratively with scientists, physicians, and engineers, from a variety disciplines as well as collaborating with citizens from affected communities.

  

Environmental chemistry and toxicology of nanomaterials

Over the past 15 years, there has been an explosion in the use of engineered nanomaterials in every facet of science and technology.  We helped to pioneer the field of environmental nanoscience. We developed tools that utilize advanced analytical, imaging and spectroscopic techniques to investigate the environmental transformations, bioavailability, bioaccumulation, trophic transfer and maternal transfer of these contaminants. We relate this information to molecular mechanisms of toxicity and adverse organismal effects with population level relevance. Our work with nanomaterials focuses on how the properties of nanomaterials relate to their bioavailability and adverse effects and how these properties change in the environment and within organisms.

 

Li et al., 2019, Environmental Science Nano, 6:273-285

   

Exposure to- and health effects of disinfection byproducts in drinking water

We work with community partners in Martin and Letcher Counties Kentucky in a community-engaged study patterns of exposure to drinking water disinfection byproducts (DBPs).  Disinfection byproducts are formed when natural organic matter (NOM) in source water reacts with chlorine or chloramine and other halogens during drinking water treatment. Examples include trihalomethanes and haloacetic acids. The most common violation of the safe drinking water act in the Commonwealth of Kentucky and nationally is for disinfection byproducts.  As many as 11 million people nationwide are exposed to levels of disinfection byproducts that exceed national standards.  DBPs have been linked to urinary tract cancers and birth defects in epidemiological studies.  Our research aims to identify the factors influencing multi-route exposure to DBPs and help prioritize engineering solutions to reduce exposure.  A key element of this research involves engagement and citizen science to help determine exposures at the level of the individual household.

      

Environmental chemistry and toxicology of trace-elements

Humans have recognized the toxicity of trace-elements such as arsenic, mercury, and lead since antiquity.  Yet wildlife and humans still often suffer adverse effects from unintentional exposure to these elements.  Over the years we have addressed a wide array of topics in trace-element toxicology with an emphasis on food chain exposure and trophic transfer, maternal transfer, soil exposure, and drinking water exposure.  Our projects have included investigation of the correlation between lung cancer and trace-element exposure in southeastern Kentucky, development of non-invasive biomarkers of children’s lead exposure, bioaccumulation and effects of mercury exposure in amphibians, metal exposure in agricultural workers in Central America, arsenic exposure from contaminated soil at a Kentucky superfund site, selenium contamination from mining sites and coal combustion products, and trophic and maternal transfer of selenium in reptiles, among other projects.

Dantzer et al., 2020, Science of the Total Environment, 700:13549

   

Nanocarriers for delivery of RNA for RNA interference technology to increase sustainability of food production

An increase in food production and decrease in food waste is needed to meet the needs of global population nearing 10 billion.  Up to a third of food is lost in the field to insect pests.  Many insects and other pests have evolved resistance to chemical pesticides.  Further chemical pesticides have historically been linked to adverse effects in humans and ecosystems.  RNA interference is a biological control method that uses RNA to suppress gene expression in target species.  However, there are barriers to the application of RNA interference technology including instability of RNA in the environment and physiological barriers that prevent delivery of dsRNA to the intracellular location of the RNAi machinery (the cytoplasm).  We have been working on developing materials to deliver dsRNA to insect pests and insect disease vectors as well as utilizing the nematode Caenorhabditis elegans as a model species to understand the mechanisms of nanocarrier-mediated RNAi.

Lichtenberg et al., 2019, Environmental Science and Technology, 53: 3832-3840.

   

SERVICE

    

Co-director of the analytical core for the National Institute of Environmental Health Sciences P30 Environmental Health Sciences Core Center (EHSCC) - University of Kentucky Center for Appalachian Research in Environmental Sciences (UK-CARES)

   

Faculty supervisor of the Plant and Soil Sciences nutrient analysis laboratory

   

Steering Committee Chair - Integrated Plant and Soil Sciences MS and PhD programs

    

 CLASSROOM-BASED TEACHING

   

PLS/TOX 560 – Ecotoxicology

PLS 581 – Chemical Analysis of Soils and Plants

PLS 772- Seminar in Plant and Soil Sciences

TOX 509 – Environmental and Regulatory Toxicology (team taught)

   

RESEARCH TRAINING

   

My lab accepts students for research training from the high school through postdoctoral levels. Examples of former mentees and their current positions are listed below.  Contact me for more information.

  

Former Postdocs

  • Simona Murph- Senior Research Scientist, Savannah River National Laboratory
  • Aaron Shoults-Wilson- Assistant Professor, Illinois Wesleyan University
  • Devrah Arndt- Scientist, Proctor and Gamble
  • Blanche Collin, Maître de Conférences (equivalent to Assistant Professor), University of Aix-Marseilles, France
  • Jérôme Laisney, Postdoctoral Fellow, University of Kentucky
  • Chun Chen- Assistant Professor, Northwest Agricultural and Forestry University, China
  • Jonathan Judy- Assistant Professor, University of Florida

   

Former Graduate Students

  • Annie Whitley- Life Scientist, United States Environmental Protection Agency
  • Emily Oostveen- Chemist, Kentucky Department of Environmental Protection
  • Sewwandi Rathnayake, PhD student, Texas A&M University
  • Jieran Li, Postdoctoral Fellow, Wayne State University
  • Stuart Lichtenberg, Postdoctoral Fellow, University of Wisconsin, Madison
  • Zeinah Elhaj Baddar, Postdoctoral Fellow, University of Georgia, Savannah River Ecology Laboratory

   

Former Undergraduate Researchers

  • Oksana Zhurbich, PhD student, Spalding University
  • Alison Willis, Environmental Scientist, University of Cincinnati
  • Julianna Dantzer, Grants Manager, Solar United Neighbors
  • Wonjin Kim, Master of Public Health Student, University of Florida
  • Yoana Cosyleon, Pollution Control Inspector, Miami Dade County Department of Environmental Resource Management.
  • Raymond Batts, CEO, Collective Minds Corporation

 

Education

  • PhD, Toxicology, The University of Georgia
  • BS, Biology, Antioch College

 

Additional Information

Click here to view Dr. Unrine’s CV and full list of publications